With the specificity and potency of biologics and the cost and ease of administration of small-molecules - wild miniproteins are the ideal modality for numerous unmet needs, including both local targeting (e.g. the gut tissue) and systemic distribution. With intrinsic bioactivity and zero immunogenicity, we are dedicated to harnessing the full potential of these extraordinary miniproteins and peptides, propelling them into the forefront of the next generation therapeutics. We created an array of tens of millions of novel structural scaffolds, a catalog which serves as a captivating foundation for an extensive library of drug-like miniproteins. Visit Wild database & catalog section.
By predicting and testing billions of links between the Wild scaffolds and human therapeutic targets and incorporating cutting-edge structural information and sequence representation techniques from large protein language models, Wildscape unlocks an unprecedented breadth of novel connections for drug discovery.
Wildscape offers an unparalleled opportunity to explore phenotype-centric (e.g. disease, animal adaptation or trait) maps and to delve into relevant, potentially newly associated targets, while exploring the extensive repertoire of therapeutic chemical space available in the Wild catalog. This comprehensive approach to drug discovery represents a groundbreaking paradigm shift in the realms of target and scaffold exploration.