Wild database & catalog

We possess the most extensive database of wildlife microbial genes ever assembled, representing a groundbreaking leap in harnessing molecular innovations forged over millions of years of evolution for therapeutic development. This unprecedented achievement opens up new vistas, enabling us to explore the vast potential of nature's molecular ingenuity on an unparalleled scale. To leverage our miniprotein-focused discovery approach, we constructed structural scaffold catalogs comprising over 60M novel scaffolds, many of them predicted as bioactive and intrinsically stable. This remarkable resource is expertly designed to facilitate function mining through mimicry, interaction, and various other approaches.

Database highlights

  • Underneath Mamba's adaptations

    Our groundbreaking research uncovers microbial miniprotein neurotoxins nestled within the mamba snake, which is known to have ability to regulate metabolism to support infrequent feeding. The discovered molecules boast unparalleled therapeutic attributes surpassing those of known analogs.

  • Mimicry for the greater good

    Microbes ingeniously employ diverse strategies to interface with their host's immune system, skillfully evading detrimental immune responses and preserving vital homeostasis. In certain instances, they harness structural resemblance without any underlying sequence homology.

  • Low metabolic (rat)e

    Naked mole-rats possess a metabolism as efficient as a cold-blooded creature, allowing them to save incredible amounts of energy. This adaptation potentially contributes to their remarkably long lifespan!

  • Madagascan fortified digestion

    The Madagascan Golden Bamboo lemur showcases such extraordinary resilience to cyanide poisoning that it can confidently consume an amount lethal to a human being.

  • Toxicity defenders

    Carrion eaters, exemplified by vultures, harbor specialized toxin-degrading bacteria within their gut, bestowing upon them the remarkable ability to safely consume decomposed flesh.

Moments to comprehend – years to actualize

A vast global network enables us to collect samples from virtually anywhere in the world, while diligent bioprospecting groundwork provides us every necessary permission. Establishing optimized protocols and procedures for preserving high-quality samples, along with fully-monitored logistic methodologies ensure the swift and safe arrival of highly perishable samples.

Diversity and functional landscapes in the microbiota of animals in the wild

See our publication in Science See all publications